COVIDelm | Result

Gene

YWHAQ

Synonyms

Protein Name

14-3-3 protein theta

UniProt ID

P27348 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000238081

NCBI Gene ID

10971

Molecular Weight

27764

Protein Length

245.0

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2btp)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cytoplasm;

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding... generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. (+)

Biological Processes

ID	Name
GO:0061024	membrane organization
GO:0034766	negative regulation of ion transmembrane transport
GO:0045892	negative regulation of transcription, DNA-templated
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0006605	protein targeting
GO:0007264	small GTPase mediated signal transduction
GO:0021762	substantia nigra development

Cellular Components

ID	Name
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular exosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0005739	mitochondrion
GO:0032991	protein-containing complex
GO:0045202	synapse

Molecular Function

ID	Name
GO:0071889	14-3-3 protein binding
GO:0042802	identical protein binding
GO:0044325	ion channel binding
GO:0008022	protein C-terminus binding
GO:0019904	protein domain specific binding
GO:0047485	protein N-terminus binding