PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha
 
              DARK BACKGROUND
Sequence Viewer
Gene
PIK3R1
Synonyms
GRB1
Protein Name
Phosphatidylinositol 3-kinase regulatory subunit alpha
UniProt ID
P27986 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000323512
NCBI Gene ID
5295
Molecular Weight
83598
Protein Length
724.0
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1a0n)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
Localization
Function
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in... glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). (+)

Gene Ontology

ID Name
GO:0007411 axon guidance
GO:0030183 B cell differentiation
GO:0001678 cellular glucose homeostasis
GO:0032869 cellular response to insulin stimulus
GO:0034644 cellular response to UV
GO:0019221 cytokine-mediated signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0038128 ERBB2 signaling pathway
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0007186 G protein-coupled receptor signaling pathway
GO:0060396 growth hormone receptor signaling pathway
GO:0008286 insulin receptor signaling pathway
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0050900 leukocyte migration
GO:0043066 negative regulation of apoptotic process
GO:0001953 negative regulation of cell-matrix adhesion
GO:0045671 negative regulation of osteoclast differentiation
GO:0051497 negative regulation of stress fiber assembly
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0006661 phosphatidylinositol biosynthetic process
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0030168 platelet activation
GO:0030335 positive regulation of cell migration
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:0051491 positive regulation of filopodium assembly
GO:0120183 positive regulation of focal adhesion disassembly
GO:0046326 positive regulation of glucose import
GO:0010592 positive regulation of lamellipodium assembly
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0042307 positive regulation of protein import into nucleus
GO:0051897 positive regulation of protein kinase B signaling
GO:1903078 positive regulation of protein localization to plasma membrane
GO:0033120 positive regulation of RNA splicing
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0032760 positive regulation of tumor necrosis factor production
GO:0006606 protein import into nucleus
GO:0006468 protein phosphorylation
GO:0050821 protein stabilization
GO:0046626 regulation of insulin receptor signaling pathway
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0034976 response to endoplasmic reticulum stress
GO:0034446 substrate adhesion-dependent cell spreading
GO:0031295 T cell costimulation
GO:0050852 T cell receptor signaling pathway
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0016032 viral process
ID Name
GO:0005911 cell-cell junction
GO:0005801 cis-Golgi network
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0005634 nucleus
GO:1990578 perinuclear endoplasmic reticulum membrane
GO:0048471 perinuclear region of cytoplasm
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005943 phosphatidylinositol 3-kinase complex, class IA
GO:0005886 plasma membrane
ID Name
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
GO:0043125 ErbB-3 class receptor binding
GO:0043559 insulin binding
GO:0005158 insulin receptor binding
GO:0043560 insulin receptor substrate binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0035014 phosphatidylinositol 3-kinase regulator activity
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
GO:0001784 phosphotyrosine residue binding
GO:0046982 protein heterodimerization activity
GO:0019903 protein phosphatase binding
GO:0008134 transcription factor binding
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity


 
Gene Ontology (maximum 10 per group shown, click on any section to view sub-classification)