COVIDelm | Result

Gene

YWHAB

Synonyms

Protein Name

14-3-3 protein beta/alpha

UniProt ID

P31946 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000300161

NCBI Gene ID

7529

Molecular Weight

28082

Protein Length

246.0

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2bq0)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cytoplasm,Melanosome;Vacuole membrane;

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding... generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. (+)

Biological Processes

ID	Name
GO:0051220	cytoplasmic sequestering of protein
GO:0035329	hippo signaling
GO:0000165	MAPK cascade
GO:0061024	membrane organization
GO:0045744	negative regulation of G protein-coupled receptor signaling pathway
GO:0035308	negative regulation of protein dephosphorylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0043085	positive regulation of catalytic activity
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0006605	protein targeting
GO:0043488	regulation of mRNA stability
GO:0016032	viral process

Cellular Components

ID	Name
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular exosome
GO:0005925	focal adhesion
GO:0042470	melanosome
GO:0016020	membrane
GO:0005739	mitochondrion
GO:0005634	nucleus
GO:0048471	perinuclear region of cytoplasm
GO:0017053	transcription repressor complex
GO:0005774	vacuolar membrane

Molecular Function

ID	Name
GO:0045296	cadherin binding
GO:0019899	enzyme binding
GO:0042826	histone deacetylase binding
GO:0042802	identical protein binding
GO:0051219	phosphoprotein binding
GO:0050815	phosphoserine residue binding
GO:0008022	protein C-terminus binding
GO:0019904	protein domain specific binding
GO:0004860	protein kinase inhibitor activity
GO:0044877	protein-containing complex binding