COVIDelm | Result

Gene

YWHAZ

Synonyms

Protein Name

14-3-3 protein zeta/delta

UniProt ID

P63104 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000309503

NCBI Gene ID

7534

Molecular Weight

27745

Protein Length

245.0

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1ib1)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cytoplasm,Melanosome;

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding... generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). (+)

Biological Processes

ID	Name
GO:0019221	cytokine-mediated signaling pathway
GO:0051683	establishment of Golgi localization
GO:0090168	Golgi reassembly
GO:0061024	membrane organization
GO:0043066	negative regulation of apoptotic process
GO:0030168	platelet activation
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0006468	protein phosphorylation
GO:0006605	protein targeting
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0043488	regulation of mRNA stability
GO:0090128	regulation of synapse maturation
GO:0007165	signal transduction
GO:0008039	synaptic target recognition

Cellular Components

ID	Name
GO:0072562	blood microparticle
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular exosome
GO:0005615	extracellular space
GO:0005925	focal adhesion
GO:0098978	glutamatergic synapse
GO:0098686	hippocampal mossy fiber to CA3 synapse
GO:0042470	melanosome
GO:0005739	mitochondrion
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0031982	vesicle

Molecular Function

ID	Name
GO:0045296	cadherin binding
GO:0042802	identical protein binding
GO:0044325	ion channel binding
GO:0019904	protein domain specific binding
GO:0019901	protein kinase binding
GO:0003723	RNA binding
GO:0008134	transcription factor binding
GO:0031625	ubiquitin protein ligase binding