| ORF3a protein
 
              DARK BACKGROUND

Hovering over the features in Protvista (below) leads to their highlighting in 3D structure.

Sequence Viewer
Gene
Protein Name
ORF3a protein
UniProt ID
P0DTC3 [go to UniProt ] [go to PDBe-KB ]
NCBI Gene ID
43740569
Molecular Weight
31123
Protein Length
275
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 6xdc)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Catalytic Site
Catalytic Site Atlas
Localization
Virion,Host cell membrane,Secreted,Host cytoplasm,Host endosome;
Function
Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Do...wnregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination. (+)

Gene Ontology

ID Name
GO:0039707 pore formation by virus in membrane of host cell
ID Name
GO:0005576 extracellular region
GO:0044178 host cell Golgi membrane
GO:0020002 host cell plasma membrane
GO:0016021 integral component of membrane
GO:0019012 virion
ID Name
GO:0005216 ion channel activity