| ORF6 protein
 
              DARK BACKGROUND

Hovering over the features in Protvista (below) leads to their highlighting in 3D structure.

Sequence Viewer
Gene
Protein Name
ORF6 protein
UniProt ID
P0DTC6 [go to UniProt ] [go to PDBe-KB ]
NCBI Gene ID
43740572
Molecular Weight
7273
Protein Length
61
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : nan)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Catalytic Site
Catalytic Site Atlas
Localization
Host endoplasmic reticulum membrane,Host Golgi apparatus membrane,Host cytoplasm;
Function
Disrupts cell nuclear import complex formation by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane. Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus. Thereby pr...events STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities (PubMed:33097660). Suppresses IFN-beta production possibly by blocking IRF3 nuclear translocation (PubMed:32979938). (+)

Gene Ontology

ID Name
GO:0009405 pathogenesis
ID Name
GO:0044167 host cell endoplasmic reticulum membrane
GO:0044178 host cell Golgi membrane
GO:0016020 membrane