| ORF9b protein
 
              DARK BACKGROUND

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Sequence Viewer
Gene
Protein Name
ORF9b protein
UniProt ID
P0DTD2 [go to UniProt ] [go to PDBe-KB ]
Molecular Weight
10797
Protein Length
97
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 6z4u)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Catalytic Site
Catalytic Site Atlas
Localization
Host cytoplasm,Host mitochondrion;
Function
Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, ca...uses mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein 1/DNM1L. (+)

Gene Ontology

ID Name
GO:0039545 suppression by virus of host MAVS activity
ID Name
GO:0044162 host cell cytoplasmic vesicle membrane
GO:0044165 host cell endoplasmic reticulum
GO:0033650 host cell mitochondrion
GO:0042025 host cell nucleus
GO:0016020 membrane
GO:0019012 virion