| ORF7a protein
 
              DARK BACKGROUND

Hovering over the features in Protvista (below) leads to their highlighting in 3D structure.

Sequence Viewer
Gene
Protein Name
ORF7a protein
UniProt ID
P0DTC7 [go to UniProt ] [go to PDBe-KB ]
NCBI Gene ID
43740573
Molecular Weight
13744
Protein Length
121
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 6w37)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Catalytic Site
Catalytic Site Atlas
Localization
Virion,Host endoplasmic reticulum membrane,Host endoplasmic reticulum-Golgi intermediate compartment membrane,Host Golgi apparatus membrane;
Function
Plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect. Acts by binding to BST2 thereby interfering with its glycosylation. May suppress small interfering RNA (siRNA). May bind to host ITGAL, thereby p...laying a role in attachment or modulation of leukocytes. (+)

Gene Ontology

ID Name
GO:0039646 modulation by virus of host G0/G1 transition checkpoint
GO:0039587 suppression by virus of host tetherin activity
GO:0039502 suppression by virus of host type I interferon-mediated signaling pathway
ID Name
GO:0044167 host cell endoplasmic reticulum membrane
GO:0044173 host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0044178 host cell Golgi membrane
GO:0016021 integral component of membrane
GO:0019012 virion